3×3 study regarding Kinisis Progen
Kinisis Progen was administered to 421 patients with joint problems from 300 physicians (orthopedics and traumatology).In cases of injuries was administered with anti-inflammatory as well.In cases of other diseases in the joints was administered alone.
• Decreases pain mainly in women and older patients.
• The general condition of the patients improved mainly in men and patients under 40.
• Improvement can be shown by the second week of treatment.
• Compared with the corresponding products, appeared to be more effective, more pleasant to take it (drink it) and with faster results.
Large number of clinical studies recording the absorption and beneficial action of enzymatically hydrolysed collagen in joints and skin.
The literature on the effect of enzymatically hydrolyzed collagen:
1. Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL), Steffen Oesser, Milan Adam, Wilfried Babel, and Jürgen Seifert
2. Identification of Food-Derived Collagen Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates, Koji Iwai, Takanori Hasegawa, Yasuki Taguchi, Fumiki Morimatsu, Kenji Sato, Yasushi Nakamura, Akane Higashi, Yasuhiro Kido, Yukihiro Nakabo, and Kozo Ohtsuki
3. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen, Oesser, S. & Seifert, J. Cell Tissue Res (2003)
4. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA), Tomáš Trč και Jana Bohmová
The literature on the effect of ursolic acid:
5. Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation. Bakhtiari N, Hosseinkhani S, Soleimani M, Hemmati R, Noori-Zadeh A, Javan M, Tashakor A.Biomed Pharmacother. 2016 Mar;78:185-96. doi: 10.1016/j.biopha.2016.01.010. Epub 2016 Feb 1.
6. Apple Pomace Extract Improves Endurance in Exercise Performance by Increasing Strength and Weight of Skeletal Muscle. Jeong JW, Shim JJ, Choi ID, Kim SH, Ra J, Ku HK, Lee
DE, Kim TY, Jeung W, Lee JH, Lee KW, Huh CS, Sim JH, Ahn YT. J Med Food. 2015 Dec;18(12):1380-6. doi: 10.1089/jmf.2014.3401. Epub 2015 Sep 2.
7. Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats.Noh KK, Chung KW,
Sung B, Kim MJ, Park CH, Yoon C, Choi JS, Kim MK, Kim CM, Kim ND, Chung HY. Mol Med Rep. 2015 Sep;12(3):3607-14. doi: 10.3892/mmr.2015.3821. Epub 2015 May
8. Ursolic acid ameliorates aging-metabolic phenotype through promoting of skeletal muscle rejuvenation.Bakhtiari N, Hosseinkhani S, Tashakor A, Hemmati R.Med Hypotheses. 2015 Jul;85(1):1-6. doi: 10.1016/j.mehy.2015.02.014. Epub 2015 Mar 2.